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129938-20-1 Medical Raw Testosterone Powder Dapoxetine Hydrochloride

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Product Description

129938-20-1 Medical Raw Testosterone Powder Dapoxetine Hydrochloride

Product Details:

Place of Origin:WuHan

Brand Name: NANJIAN

Certification:SGS

Model Number:CAS NO.: 62-90-8

Payment & Shipping Terms:

Minimum Order Quantity: 10g

Price:negotiable

Packaging Details:foil bag or tin.

Delivery Time:With 7 workdays

Payment Terms:Western union,Money gram,t/t

Supply Ability:50KG/WEEK

129938-20-1 Medical Raw Testosterone Powder Dapoxetine Hydrochloride

Detailed Product Description

Medical Raw Testosterone Powder Dapoxetine Hydrochloride CAS 129938-20-1

Dapoxetine Hydrochloride (Steroids)

Synonyms: d-Dapoxetine hydrochloride; DL-Dapoxetine hydrochloride

CAS: 129938-20-1

Assay: 98% min.

Packing: 1kg net/foil bag or tin.

Delivery: Express courier.

MF: C9H7ClN2O5

MW: 258.62

Character: White to Off-White Cyrstalline Solid, odorless, slight sweet taste, Mp 175-177℃, optical rotation +128°

Usage: Selective serotonin reuptake inhibitor (SSRI), pharmaceutical material, hormone.

980USD/500G

1. We are the manufacturer of all kinds of hormone powders. We focus on providing customers with high quality products, competitive price, best service and timely delivery.

2. Price: Please let us know the quantity you required, because for small order and bulk purchase, the price will be difference.

3. Payment methods:Western Union,MoneyGram We will supply the receiver’s information or the bank account information for payment use.

4. Shipping items: Shipping items will be delivered by international express like EMS, TNT, UPS, FEDEX or DHL after receiving received. Every item will be shipped out in 2-3 working days after the payment is done. The product usually arrives in 1-4 days based on the different destination, and online track is provided.

5. Please kindly supply the shipping address, contact and tel number for successful shipment.We are 100% confident of my shipment method.

Contraindications

A contraindication is a situation in which a drug should not be used, because it may be harmful to the patient. Dapoxetine should not be used in men with moderate to severe hepatic impairment and in those receiving CYP3A4 inhibitors such as ketoconazole, ritonavir, and telithromycine. Dapoxetine can also not be used in patients with heart failure, permanent pacemaker, or other significant ischemic heart disease. Caution is advised in men receiving thioridazine, monoamine oxidase inhibitors, SSRIs, serotonin-norepinephrine reuptake inhibitors, or tricyclic antidepressant. If a patient stops taking one of these drugs, he should wait for 14 days before taking dapoxetine. If a patient stops taking dapoxetine, he should wait for 7 days before receiving these drugs.

Adverse effects

The most common effects when taking dapoxetine are nausea, dizziness, dry mouth, headache, diarrhea, and insomnia.Discontinuation due to adverse effects is dose related. According to McMahon in recent study in Asia, the rate of discontinuation is 0.3%, 1.7%, and 5.3% of 1067 studied subjects with placebo, dapoxetine 30 mg, and dapoxetine 60 mg respectively. Unlike other SSRIs used to treat depression, which have been associated with high incidences of sexual dysfunction,[15] dapoxetine is associated with low rates of sexual dysfunction. Taken as needed, dapoxetine has very mild adverse effects on loss of libido (<1%) and ED (<4%).

Overdose

No case of the drug overdose has been reported during clinical trials.

Interactions

With phosphodiesterase inhibitors (PDE5 inhibitors)

Many men that have PE also suffer from erectile dysfunction (ED). Treatment for these patients should consider the drug-drug interaction between dapoxetine and PDE5 inhibitors such as tadalafil (Cialis) or sildenafil (Viagra). In Dresser study (2006), plasma concentration of 24 subjects was obtained. Half of the sample pool were treated with dapoxetine 60 mg + tadalafil 20 mg; the other half were treated with dapoxetine 60 mg + sildenafil 100 mg. These plasma samples were then analyzed using liquid chromatography-tandem mass spectrometry. The results showed that dapoxetine does not alter the pharmacokinetic of tadalafil or sildenafil.

With ethanol

Ethanol doesn't affect the pharmacokinetics of dapoxetine when taking concurrently with dapoxetine.

Mechanism of actions

The mechanism through which dapoxetine affects premature ejaculation is still unclear. However, it is presumed that dapoxetine works by inhibiting serotonin transporter and subsequently increasing serotonin's action at pre and postsynaptic receptors[18] Human ejaculation is regulated by various areas in the central nervous system (CNS). The ejaculatory pathway originates from spinal reflex at the thoracolumbar and lumbosacral level of spinal cord activated by stimuli from male genital. These signals are relayed to the brain stem, which then is influenced by a number of nuclei in the brain such as medial preoptic and paraventricular nulcei. Clement's study performed on anaesthetized male rats showed that acute administration of dapoxetine inhibits ejaculatory expulsion reflex at supraspinal level by modulating activity of lateral paragigantocellular nucleus (LPGi) neurons. These effects cause an increase in pudendal motoneuron reflex discharge (PMRD) latency. However, it is unclear whether dapoxetine acts directly on LPGi or on the descending pathway in which LPGi located.

Pharmacokinetics

Absorption

Dapoxetine is a white powder substance and water- insoluble. Taken 1-3 hours before sexual activity, it is rapidly absorbed in the body. Its maximum plasma concentration (Cm) is reached 1-2 hours after oral administration. The Cm and AUC (Area Under the plasma vs. time Curve) are dose dependent. The Cm and Tm (time needed to obtain the maximum plasma concentration) after single doses of dapoxetine 30 mg and 60 mg are 297 and 498 ng/mL at 1.01 and 1.27 hours respectively. A high fat meal does reduce the Cm slightly, but it is insignificant. In fact, food doesn’t alter dapoxetine pharmacokinetics. Dapoxetine can be taken with or without food.

Distribution

Dapoxetine is absorbed and distributed rapidly in the body. Greater than 99% of dapoxetine is bound to the plasma protein. The mean steady state volume is 162L. Its initial half-life is 1.31hours (30 mg dose) and 1.42 hours (60 mg dose,) and its terminal half life is 18.7 hours (30 mg dose) and 21.9 hours (60 mg dose).

Metabolism

Dapoxetine is metabolized extensively in the liver and kidney by multiple enzymes such as CyP2D6, CyP3A4, and flavin monooxygenase 1 (FMO1). The major product at the end of the metabolic pathway is circulating dapoxetine N- oxide, which is a weak SSRI and contributes no clinical effect. The other products presented less than 3% in the plasma are desmethyldapoxetine and didesmethydapoxetine, which are equipotent to dapoxetine.

Excretion

The metabolites of dapoxetine are eliminated rapidly in the urine with a terminal half-life of 18.7 and 21.9 hours for a single dose of 30 mg and 60 mg respectively.

Safety and tolerability

Cardiovascular safety

The cardiovascular safety profile of dapoxetine has been studied extensively during the drug development. Phase I trials showed that dapoxetine had neither clinical significant electrocardiographic effects nor delayed repolarization effects, with dosing up to 4-fold greater than the maximum recommended dosage which is 60 mg. Phase III studies in men with PE showed a safety and well tolerate profile of dapoxetine with dosing of 30 and 60 mg. There is no cardiovascular adverse had been found.

Neurocognitive safety

Studies of SSRIs in patients with major psychiatric disorders prove that SSRIs are potentially associated with certain neurocognitive adverse effects such as anxiety, akathisia, hypomania, changes in mood, or suicidal thought. However, there is no study on the effects of SSRIs in men with PE. McMahon’s study in 2012 showed that dapoxetine has no effect on mood and is not associated with anxiety or suicidality.

Withdrawal syndrome

The incidence of antidepressant discontinuation syndrome symptoms in men using dapoxetine to treat premature ejaculation has been described by reviewers as low and/or no different from the incidence of such symptoms in men withdrawn from placebo treatment.The lack of chronic serotonergic stimulation with on-demand dapoxetine minimizes the potentiation action of serotonin at synaptic cleft, thus decreasing the risk of DESS.

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Client Feedback:

In general, as long as the good control of the dosage, the effect is very good

129938-20-1 Medical Raw Testosterone Powder Dapoxetine Hydrochloride

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