CAS Search
Related Chemical Product
Buy Chemical NO: 91-53-2
  • Urgent Purchase CAS NO.:91-53-2
  • Please post your buying leads! Our suppliers will contact you later!
  • For suppliers to better understand your request, enter more info here.

* Product Name:
CAS No.:
* Quantity:
 
 Metric Ton     Kilogram    Gram    Pound
* Valid For:
 5 Days    15    1 Month    3 Month    6 Month    1 Year
* Description:

Max 2000 characters.  Please enter detailed description for the product.
* Email:
 

Ethoxyquin ( CASNO:91-53-2 )

Identification and Related Records
Name:
Ethoxyquin
CAS Registry number:
91-53-2
Synonyms:
6-Ethoxy-2,2,4-trimethylquinoline
6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinoline
Anti-oxidizing quinoline
1,2-dihydro-2,2,4-trimethyl-6-ethoxyquinoline
2,2,4-trimethyl-6-ethoxy-1,2-di hydroquinoline
6-ethoxy-1,2-dihydro-2,2,4-trimethyl-quinolin
6-Ethoxyl-2,2,4-trimethyl-1,2-dihydrquinoline
amea100
antageaw
AntioxidantAW
antioxidantec
Ethoxy Quinoline
EINECS(EC#):
202-075-7
Molecular Formula:
C14H19NO
Molecular Weight:
217.31
Inchi:
InChI=1/C14H19NO/c1-5-16-11-6-7-13-12(8-11)10(2)9-14(3,4)15-13/h6-9,15H,5H2,1-4H3
InChIKey:
DECIPOUIJURFOJ-UHFFFAOYSA-N
Canonical SMILES:
CCOC1=CC2=C(C=C1)NC(C=C2C)(C)C
Chemical and Physical Properties
Appearance:
yellow to red-brown liquid
Density:
1.03
Melting Point:
<0℃
Boiling Point:
123-125℃
Refractive Index:
1.569~1.571
Flash Point:
137 °C
Water:
Water Solubility:
Solubilities:
< 1 mg/ ml at 20 C
Color/Form:
YELLOW LIQUID
Stability:
Stable. Combustible. Incompatible with oxidizing agents, strong acids. Polymerizes if heated. May polymerize upon exposure to light and air.
Storage temp:
0-6°C
Spectral properties:
INDEX OF REFRACTION: 1.569-1.672 AT 25 DEG C/D
MAX ABSORPTION: 354 NM
Intense mass spectral peaks: 202 m/z (100%), 108 m/z (53%), 174 m/z (48%), 137 m/z (36%)
Computed Properties:
Molecular Weight:217.30676 [g/mol]
Molecular Formula:C14H19NO
XLogP3-AA:3.1
H-Bond Donor:1
H-Bond Acceptor:2
Rotatable Bond Count:2
Exact Mass:217.146664
MonoIsotopic Mass:217.146664
Topological Polar Surface Area:21.3
Heavy Atom Count:16
Formal Charge:0
Complexity:283
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:1
Feature 3D Donor Count:1
Feature 3D Cation Count:1
Feature 3D Hydrophobe Count:1
Feature 3D Ring Count:2
Effective Rotor Count:2.4
Conformer Sampling RMSD:0.6
CID Conformer Count:4
Safety and Handling
Hazard Codes:
Xn:Harmful
Risk Statements:
R22
Safety Statements:
S24
Skin, Eye, and Respiratory Irritations:
SKIN IRRITANT.
Transport:
200kgs
Fire Potential:
FIRE HAZARD /IS/ SLIGHT
Formulations/Preparations:
USEPA/OPP Pesticide Code 055501; Trade Names: Stop-scald.
Emulsifiable concentrate
Exposure Standards and Regulations:
Ethoxyquin is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) when intended for use in or on food it is of appropriate food grade and is prepared and handled as a food ingredient.
Ethoxyquin in animal feeds may be safely used in accordance with conditions prescribed in 21 CFR Part 573.
Ethoxyquin in certain dehydrated forage crops may be safely used in accordance with conditions prescribed in 21 CFR Part 573.
Reactivities and Incompatibilities:
Can react with oxidizing materials.
Protective Equipment and Clothing:
SKIN IRRITANT.
Specification:
The Ethoxyquin with the cas number 91-53-2, is also called 6-ethoxy-2,2,4-trimethyl-1H-quinolinenamed by IUPAC. There are also other names such as (1)6-Ethoxy-2,2,4-trimethyl-1,2-dihydrochinolin ; (2)6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline ; (3)quinoline, 6-ethoxy-1,2-dihydro-2,2,4-trimethyl- ; (4)Santoflex. It belongs to the following product categories: (1)Industrial/Fine Chemicals; (2)Inorganic & Organic Chemicals; (3)Antioxidant; (4)Biochemistry; (5)Amines; (6)Aromatics; (7)Heterocycles. Besides, it is stable, but combustible and incompatible with oxidizing agents, strong acids. And it will polymerizes if heated or may polymerize upon exposure to light and air. Physical properties about this chemical are: (1)ACD/LogP: 3.93 ; (2)# of Rule of 5 Violations: 0 ; (3)ACD/LogD (pH 5.5): 3.57 ; (4)ACD/LogD (pH 7.4): 3.92 ; (5)ACD/BCF (pH 5.5): 247.56 ; (6)ACD/BCF (pH 7.4): 559.1 ; (7)ACD/KOC (pH 5.5): 1420.5 ; (8)ACD/KOC (pH 7.4): 3208.1 ; (9)#H bond acceptors: 2 ; (10)#H bond donors: 1 ; (11)#Freely Rotating Bonds: 2 ; (12)Polar Surface Area: 12.47??2 ; (13)Index of Refraction: 1.511 ; (14)Molar Refractivity: 66.71 cm3 ; (15)Molar Volume: 222.4 cm3 ; (16)Polarizability: 26.44 ×10-24cm3 ; (17)Surface Tension: 29.7 dyne/cm ; (18)Density: 0.976 g/cm3 ; (19)Flash Point: 137.8 °C ; (20)Enthalpy of Vaporization: 57.59 kJ/mol ; (21)Boiling Point: 333.1 °C at 760 mmHg ; (22)Vapour Pressure: 0.00014 mmHg at 25°C Uses of Ethoxyquin: Ethoxyquin is a quinoline-based antioxidant used as a food preservative (E324) and a pesticide (under commercial names such as "Stop-Scald"). It is commonly used as a preservative in pet foods to prevent the rancidification of fats. Besides, Ethoxyquin is also commonly used in spices to prevent color loss due to oxidation of the natural carotenoid pigments. You can still convert the following datas into molecular structure :
(1) SMILES: O(c2ccc1c(\C(=C/C(N1)(C)C)C)c2)CC
(2) InChI: InChI=1/C14H19NO/c1-5-16-11-6-7-13-12(8-11)10(2)9-14(3,4)15-13/h6-9,15H,5H2,1-4H3 Toxic information of Ethoxyquin can be showed as follows:
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 200mg/kg (200mg/kg) ? National Technical Information Service. Vol. AD277-689,
mouse LD50 intravenous 178mg/kg (178mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: COMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Agricultural and Food Chemistry. Vol. 7, Pg. 203, 1959.
mouse LD50 oral 1584mg/kg (1584mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toksikologicheskii Vestnik. Vol. (6), Pg. 29, 1997.
rat LD50 oral 800mg/kg (800mg/kg) ? Rubber Chemistry and Technology. Vol. 45, Pg. 627, 1972.

?
Disposal Methods:
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Use and Manufacturing
Use and Manufacturing:
Methods of Manufacturing

/BY PASSING ACETONE VAPOR INTO P-PHENETIDINE CONTAINING 1% OF IODINE @ 120-130 DEG C & SEPARATING BY DISTILLATION/
Usage:
Antioxidant in feed and food; antidegradation agent for rubber.
Biomedical Effects and Toxicity
Therapeutic Uses:
(VET): Ethoxyquin is added to animal feeds at 0.015% as an antioxidant ... to help prevent encephalomalacia in growing chickens.
(VET): SANTOQUIN HAS BEEN SUCCESSFULLY USED WITH VITAMIN E IN TREATMENT OF WHITE MUSCLE DISEASE IN LAMBS.
Vitamin E and also several synthetic antioxidants, such as ... ethoxyquin, have modified tumor induction by certain carcinogens in a number of target organs. However, inhibition was achieved at high doses at which induction of biotransformation enzymes also occurs with the synthetics and, therefore, inhibition may not be due solely to antioxidant effects.
Biomedical Effects and Toxicity:
FEEDING TRIAL IN COWS WAS CONDUCTED TO DETERMINE WHETHER ETHOXYQUIN OR ITS RESIDUES ARE TRANSFERRED FROM FEED TO MILK WHEN ADDED TO COW FEED AT 0.015% OF DRY MATTER INTAKE. LESS THAN 7 UG ETHOXYQUIN/L WAS DETECTED IN MILK BY FLUORIMETRY & BY THIN-LAYER CHROMATOGRAPHY. [DUNKLEY WL ET AL; J DAIRY SCI 51 (8): 1215-8 (1968)] PubMed Abstract
(14)C-ETHOXYQUIN WAS DISTRIBUTED THROUGHOUT MOST TISSUES & BLOOD AT 0.5 HR AFTER ADMIN TO RATS. HIGHEST RADIOACTIVITY THROUGHOUT EXPERIMENT WAS OBSERVED IN LIVER, KIDNEY, GI TRACT & ADIPOSE TISSUE. THERE WAS NO ACTIVITY IN CNS. OF DOSE INGESTED BY RAT 2.2 & 0.2% WERE FOUND IN LIVER AT 0.5 HR & 6 DAYS RESPECTIVELY FOLLOWING DOSE. HEPATIC PEAK IN RADIOACTIVITY WAS MEASURED AT 8 HR; & AFTER 6 DAYS 7.5% OF THIS LEVEL WAS STILL PRESENT IN LIVER. 6 DAYS AFTER ADMIN TO RATS RESIDUES OF ETHOXYQUIN & METABOLITES WERE PRESENT IN KIDNEY CORTEX, INTESTINES, LUNG, VARIOUS ADIPOSE TISSUES & BLOOD.
The compound is readily absorbed, metabolized, and excreted in urine and feces.
Ethoxyquin residue levels in the mouse tissue were determined by the HPLC-fluorometric detection method. Mice were given powdered feed containing 0, 0.125, and 0.5% ethoxyquin hydrochloric acid and the ethoxyquin residue levels in liver kidney, lung, and brain tissues were determined after 2, 4, 6, 10, and 14 wk (4 mice/group). The tissue samples were homogenized in 10 volumes (w/v) of acetonitrile-water (7:3 v/v) centrifuged and the supernatants were stored in a freezer for 2-3 hr or until the two layers separated; then the clear upper layers were analyzed. The mean ethoxyquin residue levels in the tissue ranged 0.84-4.58 ug ethoxyquin/g liver and 0.11-0.92 ug ethoxyquin/g brain. The relative weight of the liver (5.21-7.07% body weight) and the hepatic glutathione level (5.99-7.83 uM GSH/g tissue) of mice that received ethoxyquin were significantly higher than those of the controls (4.67-5.05% body weight and 4.30-5.78 uM GSH/g tissue, respectively). The mean hepatic mitochondrial glutathione levels of the higher ethoxyquin feeding group following dietary administration of ethoxyquin for 14 wk, was approximately twofold (1.68 nM GSH/mg protein) of both the control and the lower ethoxyquin feeding groups (0.83 and 0.74 nM GSH/mg protein, respectively. [Kim HL; J Toxicol Environ Health 33 (21): 229-36 (1991)] PubMed Abstract
Chemical Company
Lianyungang Yuntai Foreign Trade Co., LTD:
 
MV Laboratories, Inc.:
profile: MV Laboratories, Corporation., manufacture ultra high-wholesomeness inorganic chemicals for chemical analytics and synthesis, very growth, NANOTECHNOLOGY, niche ceramics, and optoelectronics research and development. We stock greater than 500, pure chemicals, such as the oxides, chlorides, fluorides, Bromides, carbonates, and nitrates of 70 elements. 
Wuhan Frank Chemical Technology Co.Ltd:
 
Nantong Sane Biological Co.,Ltd:
 
Changsha Huajing Powdery Material Co.,Ltd:
Changsha Huajing Powdery Material Technological Co., Ltd,       that was established in June 2004,a higher and new-technology corporation jointed comprehensive functions of researching, developing, manufacturing, marketing in China, based on Central South University (CSU), that is a comprehensive and national key college underneath the direct administration from the Secretary of state for Education in China. In 2007,the organization established another new company named HuNan Huajing powdery material Co.,Ltd to follow along with the popularity of development. The brand new company situated in HuNan LiuYang manufacture Base, plane has greater than 30mu of space on the floor.Enterpriseis supplied with perfect production system and complete quality mo 
generic viagra online, 353455," target="_blank">generic viagra online, 353455,:
 
Wuhan Xianbao Bio-Chemical Technology Co.ltd:
 
东莞市天翊网络科技有限公司:
 
Nanjing BioTogether Co., Ltd.:
 
QINGDAO XINCHENG YIMING RUBBER MACHINERY CO., LTD:
Our Product Rubber machinery including Rubber Molding Press Machine,Website:http://www.no1rubbermach.com, Rubber Mixing Mill, Rubber Cutting Mahcine and rubber products Making lines etc. Product Application Suitable for making rubber electronic parts, automobile parts, conductive rubber, industrial oil seal, oil, sports equipment, medical equipment and all kind of vessels manufactures. Production Equipment Lathes, milling machines, drilling machines, surface grinders and others  
Minnong co.,LTD:
 
Tianjin Tuohang Chemical Co., Ltd.:
 
Nanjing Xi Ze Biological Technology Co., Ltd.:
Nanjing Xi Ze Biological Technology Co., Ltd. is really a company involved in pharmaceutical recycleables, pharmaceutical intermediates, fine chemicals R &lifier D, production and sales of high-tech businesses, company with domestic and foreign chemical companies, research institutions, universities laboratories established long-term cooperative relationship .  There's an efficient R &lifier D and salesforce, an adult technology, and Stick to market-oriented, customer interest in the recommendations, with this own knowledge and strength to carry on to build up a number of customer needs recycleables, pharmaceutical intermediates and fine chemicals.   Company sticking to the idea of quality first, follow the principle of excellent belief, and we wish to form lengthy-ter 
Handan TianEn Trade Co.,Ltd:
Our primary items are listed below 1.Pigment & Dyestuff: titanium dioxide iron oxide lithopone carbon black chrome eco-friendly 2. inorganic chemicals: zinc caustic soda aluminium sulphate sodium metabisulfite sodium tripolyphosphate those who are poly aluminium chloride soda ash calcium chloride 3. organic chemicals:ethyl acetate pentaerythritolacetic acid formic acid sodium formate boric acid oxalic acid 
Mira Biotechnology CO., Limited:
At Mira Biotechnology CO. limited, our company specializes within the manufacture and sales of botanical extracts, Natural Ingredients and High Wholesomeness Phytochemicals. Additionally, we also provide contract research outsourcing (cro) Service. Within this process, we could supply these good quality phytochemicals in milli-Gram, Gram and kilogram amounts, according to customer needs.Our ideal location in Landmass China, provides for us use of a lot of raw herbal treatments & extracts, all year long, at comparatively lower rates. There exists a group of experienced phytochemical extraction engineers and chemical analyzers .We serve major pharmaceutical companies, cosmetic companies, research institutions, Schools and colleges and the like. We be proud of our status for quality, Service  
Tianjin Yuanlong Chemical Industry Co.,Ltd:
 
Hubei Xianlin Chemical Co.,Ltd:
 
Crisschem:
Anyang Criss chemicals Co,.ltd. is affiliated to H.K. Qiduo Industry Group. Taking "be atmosphere-friendly and health" as philosophy, we're spending so much time for seeking better and better service techniques for the clients. With years' diligent, we've established manufacturing factory and materials base in Anyang city, and our manufacturing factory and materials base likes good location. At the moment, We're a specialized manufacturer and trader of Diet intensifiers, and make an effort to offer "one-stop" purchase service for the clients within the fields of APIs, Food and Cosmetics, ETC. 
LandGlass Technology Co., Ltd.26248:
AndGlass Technology Co., Ltd. (hereinafter known to as LandGlass), a hi-tech enterprise focusing within the development, manufacturing and marketing of glass tempering furnaces underneath the guidance of their philosophy of " integrity, quality, Innovation and service" that has been stuck to since its founding, is dedicated to the introduction of glass processing technologies to supply all sorts of world advanced glass tempering furnaces for clients to assist them to upgrade their items and make continuous progress in technological Innovation.To date, LandGlass has built the whole number of technical solutions for that flat and bent tempered glass items to satisfy the requirements in architectures, furniture, household home appliances, automobiles and Solar power industries. You will find  
465724SX54ScsdaAD: