CAS Search
Related Chemical Product
Buy Chemical NO: 7491-74-9
  • Urgent Purchase CAS NO.:7491-74-9
  • Please post your buying leads! Our suppliers will contact you later!
  • For suppliers to better understand your request, enter more info here.

* Product Name:
CAS No.:
* Quantity:
 
 Metric Ton     Kilogram    Gram    Pound
* Valid For:
 5 Days    15    1 Month    3 Month    6 Month    1 Year
* Description:

Max 2000 characters.  Please enter detailed description for the product.
* Email:
 

Piracetam ( CASNO:7491-74-9 )

Identification and Related Records
Name:
Piracetam
CAS Registry number:
7491-74-9
Iupac name:
2-(2-oxopyrrolidin-1-yl)acetamide
Synonyms:
Myocalm
Neuracetam
Nootobril
Nootobryl
Nootron
Nootrop
Nootropil
Nootropyl
Normabrain
Norzetam
(2-Oxopyrrolidino)acetamide
2-(2-Oxopyrrolidin-1-yl)acetamide
2-Ketopyrrolidine-1-acetamide
2-Oxo-1-pyrrolidineacetamide
2-Oxo-1-pyrrolidinylacetamide
2-Pyrrolidinoneacetamide
2-Pyrrolidoneacetamide
Avigilen
Axonyl
Cerebroforte
Cl 781
Encetrop
Euvifor
Gabacet
Genogris
Geram
EINECS(EC#):
231-312-7
Molecular Formula:
C6H10N2O2
Molecular Weight:
142.16
Inchi:
InChI=1/C6H10N2O2/c7-5(9)4-8-3-1-2-6(8)10/h1-4H2,(H2,7,9)
InChIKey:
GMZVRMREEHBGGF-UHFFFAOYSA-N
Canonical SMILES:
C1CC(=O)N(C1)CC(=O)N
Chemical and Physical Properties
Density:
1.239 g/cm3
Melting Point:
151-152 °C
Boiling Point:
408.3 °C at 760 mmHg
Refractive Index:
1.523
Flash Point:
200.8 °C
Solubilities:
Very soluble
Color/Form:
Crystals from isopropanol
Stability:
Stable at normal temperatures and pressures.
Storage temp:
Keep tightly closed.
Computed Properties:
Molecular Weight:142.1558 [g/mol]
Molecular Formula:C6H10N2O2
XLogP3-AA:-1.3
H-Bond Donor:1
H-Bond Acceptor:2
Rotatable Bond Count:2
Tautomer Count:6
Exact Mass:142.074228
MonoIsotopic Mass:142.074228
Topological Polar Surface Area:63.4
Heavy Atom Count:10
Formal Charge:0
Complexity:167
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:2
Feature 3D Donor Count:1
Feature 3D Ring Count:1
Effective Rotor Count:2.8
Conformer Sampling RMSD:0.6
CID Conformer Count:5
Safety and Handling
Hazard Codes:
Xi: Irritant;
Risk Statements:
R36/37/38
Safety Statements:
26-37/39
Safety:
Hazard Codes:?IrritantXi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: UX9660500
Formulations/Preparations:
Nootropil 800 and 1200 mg Tablets: Polyethylene glycol 6000, Colloidal anhydrous silica, Magnesium stearate, Methocel, Titanium dioxide (E171), Polyethylene glycol 400. Nootropil Solution 33%: Glycerol, Methyl parahydroxybenzoate, Propyl parahydroxybenzoate, Sodium acetate, Acetic acid, Purified water
Avigilen
Axonyl
Ciclofalina
Cerebroforte
Encetrop
Gabacet
Genogris
Geram
Nootrop
Nootropil
Nootropyl
Norzetam
Normabrain
Piracebral
Pirroxil
Pyramem
Piracetrop
Sinapsan
Specification:
?Piracetam , its cas register number is 7491-74-9. It also can be called 1-Acetamido-2-pyrrolidinone ; 2-Ketopyrrolidine-1-ylacetamide ; 2-Oxo-1-pyrrolidineacetamide ; 2-Oxo-pyrrolidin-1-ylacetamide ; 2-Oxo-pyrrolidine acetamide ; 1-Pyrrolidineacetamide, 2-oxo- .It is?very soluble?in water.
Octanol/Water Partition Coefficient:
log Kow = -1.54
Disposal Methods:
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Use and Manufacturing
Use and Manufacturing:
Methods of Manufacturing

... Prepared by condensing 2-pyrrolidinone with ethyl chloroacetate in the presence of a metal hydride and then converting the ester into an amide with ammonia.
Prepn: H. Morren, NL 6509994; eidem, US 3459738 (1966, 1969 both to U.C.B)
Usage:
Medication.
Biomedical Effects and Toxicity
Biological Activity:
Nootropic that displays cognitive enhancing properties. Proposed to enhance neurotransmission via modulation of ion flux; potentiates Na + influx through AMPA receptors. Facilitates efficiency of cholinergic neurotransmission at muscarinic receptors.
Pharmacological Action:
- Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
- Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.
Therapeutic Uses:
/Investigators/ report on a 30-year-old patient with advanced cerebellar degeneration due to sickle cell amemia 2. He presented with severe myoclonus, which was resistant to conventional therapy and dramatically improved after administration of 12-18 g/day piracetam. Piracetam may be considered in the treatment of refractory myoclonus in spinocerebellar degenerations. [De Rosa A et al; Mov Disord 21 (1): 116-8 (2006)]
Biomedical Effects and Toxicity:
Piracetam is rapidly and almost completely absorbed. Peak plasma levels are reached within 1.5 hours after administration. The extent of oral bioavailability, assessed from the Area Under Curve (AUC), is close to 100% for capsules, tablets and solution.
Peak levels and AUC are proportional to the dose given. The volume of distribution of piracetam is 0.7 L/kg, and ... Clearance of the compound is dependent on the renal creatinine clearance and would be expected to diminish with renal insufficiency.
Piracetam is excreted in human breast milk.
Piracetam crosses the blood-brain and the placental barrier and diffuses across membranes used in renal dialysis.
Piracetam is excreted almost completely in urine and the fraction of the dose excreted in urine is independent of the dose given.
Chemical Company
suntton(CHINA):
 
SHENZHEN ZONEWINS SPECIAL MATERIALS CO.,LTD.:
 
Zhejiang Yiwu City Dongrong Jewelry Co.,Ltd:
Yiwu City Dongrong Jewelry Co.,Ltd is a professional fashion jewelry production and sales integration company located ed in China Yiwu city,Website:http://www.ywdrjewelry.com, we have our own design research and development team, our own brand ALLENCOCO is famous in many countries like USA, RUSSIA, Germany, Pakistan, Mexico, Canada and so on, Our main jewelry are Ring, earring, necklace, bracelet, brooch and jewelry set, we provide different materials for choosing, e.g. zinc alloy, copper alloy, sterling silver, stainless steel, pearl, shell. Welcome customer's own designs, OEM&ODM order are all accepted, look forward to your visit and cooperation! 
Liulin I/E (Hebei) Co., Ltd.:
LIULIN I/E (Hebei) CO., Ltd. is definitely an import and export buying and selling enterprise in neuro-scientific chemical items covering inorganic chemicals, agriculture fertilizer organic intermediates of pharmaceutical and dyestuff. Since founded in 2002,we've established good relations because of so many clients both from China and Overseas. the organization is going through the market by supplying high-quality items, and has satisfied the foreign clients with excellent service " Honest business and diligent, Serving our clients" is our tenet and supreme target. LIULIN sincerely wishes to make cooperation along with you. 
Handan Guangzheng Disinfectant Co., Ltd:
Handan Guangzheng Disinfectant Co., Ltd is an expert in producing disinfectants. Additionally to abundant funds and Assets, we possess advanced equipment in addition to technologies to the date. Among 500 employees, 30 are senior specialists. 6,000 metric a lot of Sodium dichloroisocyanurate and 4,500 metric tons oftrichloroisocyanuric acidity emerge from the industrial facilities every year. Simultaneously the annual output ofcyanuric acidity comes down to 13,000 metric tons. Our items happen to be being released to Japan, USA and EU. Clients praise highly in our items.  
HEBEI SHUNDA IMP & EXP CO.,LTD.:
Like a professional chemical synthesis supplier, HEBEI SHUNDA IMP &lifier EXP CO.,Ltd. is focused on buying and selling and developing active pharmaceutical components, Intermediates, and API. Besides, we value more special service, That's, to personalize chemical synthesis based on client&rsquos needs. Because of our partners, we own independent R&D center in Hebei province and plants in Shanxi province. All of our manufacture bases and facilities are GMP approved. Based on our highly qualified group of professionals and specialists, we've wealthy experience of an outrageous selection of chemical responses from mg scale to metric a lot of scale based on clients&rsquo needs. HEBEI SHUNDA IMP &lifier EXP CO.,Ltd. is really a qualified company within the chemical field. we've pr 
Shanghai Dian Yang Industry Co., Ltd:
Shanghai DianYang Industrial Co., Ltd.,Website:http://www.ch-dyc.com, with factory, AnHui ShengHong Electronics Co., Ltd., was found in 2007 in Shanghai.?As of?rapid development of electronic technology, our company developed from a single line supplier/manufacturer at first to the series products supplier/manufacturer nowadays with import and export license. Barium Titanate (BaTiO3), Magnesium Titanate (MgTiO3), Strontium Titanate (SrTiO3), Potassium Titanate (K2TiO3), Sodium Titanate (NaTiO3), Potassium Titanate Sodium (NBT), Potassium Titanate Whiskers (PTW), Barium Strontium Titanate (BST), Calcium Copper Titanate (CCTO), Calcium Titanate (CaTiO3) and some other Perovskite Titanate, and functional ceramic materials related to Ceramic dielectric properties, such as Capacitor Material, P 
465724SX54ScsdaAD:
 
465724SX54ScsdaAD:
 
ChengDu Climb Pharmaceutical Technology Co., Ltd.:
ChengDu Climb Pharmaceutical Technology Co., Ltd. is really a high-tech enterprise focused on new drug's R&D,manufacturing and sales.Our products(APIs &Intermediates) are suitable for anti-infective, heart, Anti-diabetic, anti- cancer, central nervous system, intestinal tract and digestive tract.We've passionate professionals within our research &lifier team of developers with decades of expertise in pharmaceutical industry.Our productions derive from top quality management system, perfect facilities and top class pilot plants.   
Zannan Pharma, Ltd.:
 
Beijing Mesochem Technology Co.,LTD.:
 
Shaanxi wantong automation equipment Co.,Ltd:
 
Shenzhen XINZHENHUI Sealing Technology Co.,Ltd:
Shenzhen XINZHENHU Sealing Technology Co.,Ltd was established in Shenzhen,Website:http://www.xzhrubbers.com, China, 1999. The factory area is 5000 suqare meters, with 26 advanced molding machines , 8 sets CNC and over 120 employees. Vacuum suction cups are our main products. They are widely used for industrial automation field, such as manipulator, galss, automobile , packing, electronic components etc. Also we can produce all kinds of rubber molded products, o-rins, V-ring, U-ring,gasket, washer, grommet, bellows, oil seal, joint seal, Conductive silicone rubber tips, rubber cord, rubber fabric diaphragm, rubber bonded with metal &plastic etc. We also offer the custom molded produ 
Hangzhou Garden Trading Co.,Ltd.:
 
Zhengzhou Hing electrical equipment company limited:
 
Huzhou City Linghu Xinwang Chemical Co.,Ltd.:
 
Premier Chemical Products Researchers:
 
WHOSH Limited Company UW:
HNB? We are a leading contract manufacturer of ingredient for dietary supplements,Website:http://www.whoshasia.asia, food and cosmetic markets. HNB?’s advanced technology and innovative research in Marine collagen manufacturing and application are recognized as outstanding contribution to the industry development. And in 2014 May, HNB was honored with top award by China National Government. HNB? is an ISO22000 and HALA certified company that operates out of its 180,000 sq. ft. workshop located in the capital of Zhejiang Province in CHINA. Assured by expertise and knowledge, HNB? products are considered as the highest standard quality from lot-to-lot and are easy-to-use. 
SunaTech Inc.: