CAS Search
Related Chemical Product
Buy Chemical NO: 7491-74-9
  • Urgent Purchase CAS NO.:7491-74-9
  • Please post your buying leads! Our suppliers will contact you later!
  • For suppliers to better understand your request, enter more info here.

* Product Name:
CAS No.:
* Quantity:
 
 Metric Ton     Kilogram    Gram    Pound
* Valid For:
 5 Days    15    1 Month    3 Month    6 Month    1 Year
* Description:

Max 2000 characters.  Please enter detailed description for the product.
* Email:
 

Piracetam ( CASNO:7491-74-9 )

Identification and Related Records
Name:
Piracetam
CAS Registry number:
7491-74-9
Iupac name:
2-(2-oxopyrrolidin-1-yl)acetamide
Synonyms:
Myocalm
Neuracetam
Nootobril
Nootobryl
Nootron
Nootrop
Nootropil
Nootropyl
Normabrain
Norzetam
(2-Oxopyrrolidino)acetamide
2-(2-Oxopyrrolidin-1-yl)acetamide
2-Ketopyrrolidine-1-acetamide
2-Oxo-1-pyrrolidineacetamide
2-Oxo-1-pyrrolidinylacetamide
2-Pyrrolidinoneacetamide
2-Pyrrolidoneacetamide
Avigilen
Axonyl
Cerebroforte
Cl 781
Encetrop
Euvifor
Gabacet
Genogris
Geram
EINECS(EC#):
231-312-7
Molecular Formula:
C6H10N2O2
Molecular Weight:
142.16
Inchi:
InChI=1/C6H10N2O2/c7-5(9)4-8-3-1-2-6(8)10/h1-4H2,(H2,7,9)
InChIKey:
GMZVRMREEHBGGF-UHFFFAOYSA-N
Canonical SMILES:
C1CC(=O)N(C1)CC(=O)N
Chemical and Physical Properties
Density:
1.239 g/cm3
Melting Point:
151-152 °C
Boiling Point:
408.3 °C at 760 mmHg
Refractive Index:
1.523
Flash Point:
200.8 °C
Solubilities:
Very soluble
Color/Form:
Crystals from isopropanol
Stability:
Stable at normal temperatures and pressures.
Storage temp:
Keep tightly closed.
Computed Properties:
Molecular Weight:142.1558 [g/mol]
Molecular Formula:C6H10N2O2
XLogP3-AA:-1.3
H-Bond Donor:1
H-Bond Acceptor:2
Rotatable Bond Count:2
Tautomer Count:6
Exact Mass:142.074228
MonoIsotopic Mass:142.074228
Topological Polar Surface Area:63.4
Heavy Atom Count:10
Formal Charge:0
Complexity:167
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:2
Feature 3D Donor Count:1
Feature 3D Ring Count:1
Effective Rotor Count:2.8
Conformer Sampling RMSD:0.6
CID Conformer Count:5
Safety and Handling
Hazard Codes:
Xi: Irritant;
Risk Statements:
R36/37/38
Safety Statements:
26-37/39
Safety:
Hazard Codes:?IrritantXi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: UX9660500
Formulations/Preparations:
Nootropil 800 and 1200 mg Tablets: Polyethylene glycol 6000, Colloidal anhydrous silica, Magnesium stearate, Methocel, Titanium dioxide (E171), Polyethylene glycol 400. Nootropil Solution 33%: Glycerol, Methyl parahydroxybenzoate, Propyl parahydroxybenzoate, Sodium acetate, Acetic acid, Purified water
Avigilen
Axonyl
Ciclofalina
Cerebroforte
Encetrop
Gabacet
Genogris
Geram
Nootrop
Nootropil
Nootropyl
Norzetam
Normabrain
Piracebral
Pirroxil
Pyramem
Piracetrop
Sinapsan
Specification:
?Piracetam , its cas register number is 7491-74-9. It also can be called 1-Acetamido-2-pyrrolidinone ; 2-Ketopyrrolidine-1-ylacetamide ; 2-Oxo-1-pyrrolidineacetamide ; 2-Oxo-pyrrolidin-1-ylacetamide ; 2-Oxo-pyrrolidine acetamide ; 1-Pyrrolidineacetamide, 2-oxo- .It is?very soluble?in water.
Octanol/Water Partition Coefficient:
log Kow = -1.54
Disposal Methods:
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Use and Manufacturing
Use and Manufacturing:
Methods of Manufacturing

... Prepared by condensing 2-pyrrolidinone with ethyl chloroacetate in the presence of a metal hydride and then converting the ester into an amide with ammonia.
Prepn: H. Morren, NL 6509994; eidem, US 3459738 (1966, 1969 both to U.C.B)
Usage:
Medication.
Biomedical Effects and Toxicity
Biological Activity:
Nootropic that displays cognitive enhancing properties. Proposed to enhance neurotransmission via modulation of ion flux; potentiates Na + influx through AMPA receptors. Facilitates efficiency of cholinergic neurotransmission at muscarinic receptors.
Pharmacological Action:
- Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
- Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.
Therapeutic Uses:
/Investigators/ report on a 30-year-old patient with advanced cerebellar degeneration due to sickle cell amemia 2. He presented with severe myoclonus, which was resistant to conventional therapy and dramatically improved after administration of 12-18 g/day piracetam. Piracetam may be considered in the treatment of refractory myoclonus in spinocerebellar degenerations. [De Rosa A et al; Mov Disord 21 (1): 116-8 (2006)]
Biomedical Effects and Toxicity:
Piracetam is rapidly and almost completely absorbed. Peak plasma levels are reached within 1.5 hours after administration. The extent of oral bioavailability, assessed from the Area Under Curve (AUC), is close to 100% for capsules, tablets and solution.
Peak levels and AUC are proportional to the dose given. The volume of distribution of piracetam is 0.7 L/kg, and ... Clearance of the compound is dependent on the renal creatinine clearance and would be expected to diminish with renal insufficiency.
Piracetam is excreted in human breast milk.
Piracetam crosses the blood-brain and the placental barrier and diffuses across membranes used in renal dialysis.
Piracetam is excreted almost completely in urine and the fraction of the dose excreted in urine is independent of the dose given.
Chemical Company
Shanghai Rainbow Enterprise Development Co.,Ltd:
Shanghai Rainbow Enterprise Development Co.,Ltd was established in 2008.We are a professional team with more than 20-years experiences in productinog scarves,Website:http://www.shrainbowblanket.com,blankets and sweaters.We are expert in exporting cashmere,wool,and acrylic products.We have worldwide clients mostly from United States,Germany,Brazil,Italy,Japan,Korea and Hongkong.For Enquiries and further services,please feel free to contact us.We will respond you within 8 hours. 
Zibo lanyin Chemical Co,.Ltd:
 
Shijiazhuang Zhongshuo Pharmaceutical Co., Ltd.:
 
Shanxi Linfen Dyeing Chemicals Co.,Ltd.:
It's the greatest enterprise using its number of SULPHUR BLACK on the planet.It's the greatest enterprise using its number of VAT PINK on the planet.Among the 500 greatest chemical industry businesses, the 20 greatest dyeing industry ones.it passed the ISO9001 quality system certification.It had been produced in 1960 and cool to become a limited corporation company in 1997.It can produce six style dyes (including sulphur, vat, ETC) and Dyestuff Intermediates, medicine intermediates which can be over 80 kinds.Sulphur black marked Huanyu grew to become the very best brand product in Shanxi province in 2001, 2003 and 2005.It is the owner of the provincial class technical center and is furnished using the top class checking instrument.It is the owner of the right atmosphere protection and chec 
Henan Huixian Quanxi Chemical Factory:
profile: Henan Huixian Quanxi Chemical Factory is an expert in fine chemicals. Our items include acetyl bromide, Propionyl bromide, bromo acetyl bromide, 2 -bromo Propionyl bromide, bromoacetate, bran chloride, trimethyl acetyl bromide and nitrobenzyl alcohol. We offer intermediates for example P-methoxy-a-chloroacetophenone, P-methoxy-a-bromoacetophenone and a-bromoacetophenone. 
Huzhou Shuanglin Hengxing Polishing Equipment Factory:
HUZHOU SHUANGLIN HENGXING POLISHING EQUIPMENT FACTORY established in 1980s is one of the well-know manufacture of surface finishing industry in China. HENGXING dedicates to providing high quality products and advanced technology on surface polishing for customers and manufactures from all type of industries. HENGXING will persistently provide reliable quality products and high quality service to customers through R&D development and professional management in future. Website:http://www.hxpolishing.com 
Boilys & Co:
 
WEIHAI GUANGWEI COMPOSITES CO.,LTD LT:
Founded in 1992,Website:http://www.gwcarbonfibre.com, Weihai Guangwei Composites Co., Ltd. integrates research, development and production of?advanced composites and professionally provides reinforced fiber fabric, prepregs and composite products. The company has a registered capital of RMB 0.68 billion, a floor area of 0.2 million square meter and total assets of RMB 1.45 billion. The company has advanced production and testing equipment from such as Japan, the United States and Germany, and annual productivities of 5 million square meters of reinforced fiber fabric, 20 million square meters of prepregs and 0.1 million pieces of profiled bars and realizes the batch production of composite products - boards and pipes. Our composites and products are widely applied in wind power industr 
xianxujiletianyiqiyibiaoyouxiangongsi:
 
Hebei Jinding Copper Co,Ltd:
  HeBei Jindingcopper Co.,LTD is really a massive Copper Sulfate &lifier Copper Oxide Manufacturer in North of China. Throughout the fifteen years development, We innovate and optimize items for that market. The Electroplating Grade, TECH GRADE, Feed Grade, Farming Grade Copper Sulfate and Copper Oxide are our advantaged items. And our items happen to be released in the usa, Canada, Australia, Nigeria, Nz, Belgium, Japan, Southeast Asia etc.       Our Goal: Carry forward spirit of enterprice” Study ,overcome , precede,” , shoot for a sizable goal as &ldquo being completely recognized by individuals of the identical trade and bringing in wordwide attention.&rdquo We sincerely welcomes clients and buddies at domestic and abroad arrive at execute wi 
Suzhou Power Meter Co.ltd:
Suzhou Power Meter Co;Ltd is a professional instruments' dial and meter manufacturer set up in the year 1995,Website:http://www.power-gaugess.com, located in the famous sites “ Hill Tiger” Suzhou. We specialize in designing, manufacturing and exporting all kinds of dry pressure gauge, liquid filled pressure gauge , thermometer, instrument panel, nameplate, signs, indicator board, circuit board in different spec and material. With more than 50 experienced staffs working in the technical department, we can process material ranging from aluminums, copper, stainless steel, PC,PVC,PET and organic glass, and our technology including etching, polishing, aluminum oxidating,spray sand,coloured screen printing, plate making of computer, and photomechanical process.? Our annual output for pressure ga 
Wuxi Conson Finechemical Co., Ltd.:
profile: Wuxi Conson Finechemical Co., Ltd. is really a manufacturer of medicinal intermediates. Our items include 4-chloro-2-nitrobenzoic acidity, 2-amino-4-chlorobenzoic acidity(4-chloroanthranilic acidity), 2-amino-4-chlorobenzonitrile(5-chloro-2-cyanoaniline), 5"(4-chloro-2-aminophenyl)tetrazole, 2,6-difluorobenzonitrile, Ethyl gallate(ethyl 3,4,5-trihydroxybenzoate), 3,4,5-trimethoxybenzonitrile,Copper Pyrithione, copper 2-pyridinethiol-1-oxide, 2,3,4-trihydroxybenzaldehyde andzinc pyrithione. 
Shannxi Zhengbang Biological Science & Technology Co.,Ltd:
 
Zhejiang Deju Aluminum Co., Ltd:
We are supplier of color coated aluminum coil,Website:http://www.dejualuminum.com, especially at wooden / marble /chameleon / mirror... our company is near Shanghai, and welcome for your visit. 
465724SX54ScsdaAD:
 
Tianjin Beisier Chemical Co, Ltd:
Tianjin Beisier Chemical Co., Ltd is really a large-scale chemical enterprise which commits to production, research and purchase. It keeps a yearly export value over USD 20 million. Our items include Ti series,phosphorus series, plasticizer and ETC. These items have been in a number one position in Chinese chemical industry, and have won the trust and praise in the clients in the domestic and abroad.  
Yiling Pharma Group:
 
Shenzhen Tuofa Technology Co., Ltd.:
Shenzhen Tuofa Technology co.,Ltd specializes in manufacturing of precision machine parts,Website:http://www.tuofamachinings.com,the company not only has numerous advanced machine equipment such as cnc machining centre, high speed drilling and milling machining center, cnc lathe etc.the inspection equipment including callipers, two dimensional measuring instrument,height gauge etc.but also has a team with professional and highly qualified mechanic talent. we have rich experience in machining stainless steel, titanium alloy,aluminum, brass parts, As well as providing all kinds of precision parts to the Lithium battery equipment,medical equipment, automobile assembly equipment, liquid crystal manufacturing equipment,optical communication equipment,Optical lenses,endoscope industry etc 
Sichuan Hongguang Chemical Co.,Ltd.:
 
465724SX54ScsdaAD: