CAS Search
Related Chemical Product
Buy Chemical NO: 26787-78-0
  • Urgent Purchase CAS NO.:26787-78-0
  • Please post your buying leads! Our suppliers will contact you later!
  • For suppliers to better understand your request, enter more info here.

* Product Name:
CAS No.:
* Quantity:
 
 Metric Ton     Kilogram    Gram    Pound
* Valid For:
 5 Days    15    1 Month    3 Month    6 Month    1 Year
* Description:

Max 2000 characters.  Please enter detailed description for the product.
* Email:
 

Amoxicillin ( CASNO:26787-78-0 )

Identification and Related Records
Name:
Amoxicillin
CAS Registry number:
26787-78-0
Synonyms:
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-, D- (8CI)
Eupensol
Excillin
Farconcil
Fisamox
Foxolin
Fullcilina
Gemox
Gimalxina
Gomcillin
Gramidil
Grunamox
Hiconcil
Hipen
Histocillin
Hosboral
Imacillin
Imaxilin
Imox
Imoxil
Intermox
Jerramcil
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, [2S-[2a,5a,6b(S*)]]-
6-[D-(-)-p-Hydroxy-a-aminobenzyl]penicillin
6-[D-a-Amino-a-(4-hydroxyphenyl)acetamido]penicillanicacid
A-Gram
Actimoxi
Agerpen
Alfamox
Almodan
Alphamox
Amagesen Solutab
Amodex
Amoflux
Amopenixin
Amoxa
Amoxal
Amoxapen
Amoxaren
Amoxi
Amoxi-Mast
Amoxicilina
Amoxidal
Amoxiden
Amoxil
Amoxin
Amoxipen
Amoxtrex
Amoxy
Amoxypen
Ampidroxyl
Ampy-Penyl
Anemol
Anemolin
Apitart
Apo-Amoxi
Ardine
Aspenil
Audumic
BLP1410
BRL 2333
Bactox
Betamox
Bimox
Biomox
Bioxidona
Bioxyllin
Cabermox
Cilamox
Clamox
Clamoxyl
Coamoxin
Comoxyl
D-(-)-a-Amino-p-hydroxybenzyl penicillin
D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid
D-Amoxicillin
Delacillin
Efpenix
Efpinex
Eupen
EINECS(EC#):
248-003-8
Molecular Formula:
C16H19N3O5S
Molecular Weight:
365.4
Inchi:
InChI=1/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14-/m1/s1
Canonical SMILES:
CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C
Isomers smiles:
CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)C(=O)O)C
Chemical and Physical Properties
Appearance:
solid
Density:
1.54g/cm3
Boiling Point:
743.2 °C at 760 mmHg
Vapour:
3.39E-23mmHg at 25°C
Flash Point:
403.3 °C
Solubilities:
1 g soluble in about 370 ml
Stability:
Stable. Incompatible with strong oxidizing agents.
Storage temp:
2-8°C
Spectral properties:
SPECIFIC OPTICAL ROTATION: +248 DEG TO +268 DEG
Computed Properties:
Molecular Weight:365.40416 [g/mol]
Molecular Formula:C16H19N3O5S
XLogP3:-2
H-Bond Donor:4
H-Bond Acceptor:7
Rotatable Bond Count:4
Tautomer Count:8
Exact Mass:365.104541
MonoIsotopic Mass:365.104541
Topological Polar Surface Area:158
Heavy Atom Count:25
Formal Charge:0
Complexity:590
Isotope Atom Count:0
Defined Atom Stereocenter Count:4
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:4
Feature 3D Donor Count:3
Feature 3D Anion Count:1
Feature 3D Cation Count:1
Feature 3D Hydrophobe Count:1
Feature 3D Ring Count:2
Effective Rotor Count:5.8
Conformer Sampling RMSD:0.8
CID Conformer Count:29
Safety and Handling
Hazard Codes:
Xn:Harmful
Risk Statements:
R42/43
Safety Statements:
S22;S36/37
Safety:
Hazard Codes :?HarmfulXn,IrritantXi
Risk Statements : 42/43?
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements : 22-36/37?
S22:Do not breathe dust.?
S36/37:Wear suitable protective clothing and gloves.
WGK Germany : 2
RTECS : XH8300000
Formulations/Preparations:
AMOXICILLIN (AMOXIL, LAROTID) IS AVAILABLE FOR ORAL USE IN CAPSULES (250 OR 500 MG), AS ORAL SUSPENSION (125 OR 250 MG/5 ML), & AS PEDIATRIC DROPS (50 MG/ML).
Exposure Standards and Regulations:
Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).
Specification:
? Amoxicillin ,?its cas register number is 26787-78-0. It also can be called?6-(D-(-)-alpha-Amino-p-hydroxyphenylacetamido)penicillanic acid ; 6-(D-(-)-p-Hydroxy-alpha-aminobenzyl)penicillin ; 6-(p-Hydroxy-alpha-aminophenylacetamido)penicillanic acid?; Amoclen ; Amolin ; Amopenixin ; Amoxi ; Amoxi-Mast ;Amoxicaps ; Amoxicilina ; Amoxicillin pediatric ; Amoxicilline ; Amoxicillinum Amoxiden ; Amoxil ; Amoxivet ; D-(-)-alpha-Amino-p-hydroxybenzylpenicillin ; D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid ; D-Amoxicillin ; Delacillin ; DisperMox ; Hiconcil ; Histocillin ; Ibiamox ; Imacillin ; Larotid ; Metafarma capsules ; Metifarma capsules ; Moxacin ; Moxal ; Wymox ; alpha-Amino-p-hydroxybenzylpenicillin ; p-Hydroxyampicillin .
Disposal Methods:
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Use and Manufacturing
Use and Manufacturing:
Methods of Manufacturing

BY ACETYLATING 6-AMINOPENICILLANIC ACID WITH D-(-)-2-(P-HYDROXYPHENYL)-GLYCINE.
Usage:
Medication.
Biomedical Effects and Toxicity
Pharmacological Action:
- Substances that reduce the growth or reproduction of BACTERIA.
Therapeutic Uses:
Penicillins
ANTIMICROBIAL SPECTRUM OF AMOXICILLIN IS ESSENTIALLY IDENTICAL TO THAT OF AMPICILLIN, WITH IMPORTANT EXCEPTION THAT AMOXICILLIN APPEARS TO BE LESS EFFECTIVE THAN AMPICILLIN FOR SHIGELLOSIS.
RECOMMENDED DOSE OF AMOXICILLIN IS SIMILAR TO THAT OF AMPICILLIN ... EXCEPT THAT IT IS GIVEN 3 INSTEAD OF 4 TIMES A DAY.
Amoxicillin /is/ indicated in the treatment of acute otitis media caused by susceptible organisms. /Included in US product labeling/
Amoxicillin /is/ indicated in the treatment of bacterial pharyngitis caused by susceptible organisms. /Included in US product labeling/
Amoxicillin /is/ indicated in the treatment of bacterial pneumonia caused by susceptible organisms. /Included in US product labeling/
Amoxicillin /is/ indicated in the treatment of sinusitis caused by susceptible organisms. /Included in US product labeling/
Amoxicillin, in combination with probenecid, and (penicillin G parenteral (NOT included in US product labeling)) are indicated in the treatment of gonorrhea caused by susceptible strains of Neisseria gonorrhoea. However, because of resistance to penicillin, other agents, such as ceftiraxone, cefixime, or ciprofloxacin, are considered to be first-line agents. /Included in US product labeling/
Amoxicillin /is/ indicated in the treatment of bacterial urinary tract infections caused by susceptible organisms. /Included in US product labeling/
Amoxicillin /is/ indicated in the treatment of chlamydia infections in pregnant women who cannot tolerate erythromycin. /NOT included in US product labeling; Not included in Canadian product labeling/
Amoxicillin and penicillin V are used in the treatment of early Lyme disease, caused by Borrelia burgdorferi. Amoxicillin in combination with probenecid, and penicillin G (parenteral) are used to treat more advanced stages of Lyme disease, including mild neurological manifestations, cardiac manifestations, and arthritis. /NOT included in US product labeling; Not included in Canadian product labeling/
Amoxicillin is used, in combination with metronidazole and bismuth subsalicylate, in the treatment of gastritis and peptic ulcer disease caused by Helicobacter pylori. /Included in US product labeling/
Amoxicillin /is/ used in the treatment of typhoid fever caused by Salmonella typhi. /NOT included in US product labeling; Not included in Canadian product labeling/
Amoxicillin ... /is/ indicated in the treatment of bronchitis caused by susceptible organisms. /Included in US product labeling/
Amoxicillin /is/ indicated in the prophylaxis of bacterial endocarditis caused by susceptible organisms. /Included in US product labeling; Not included in Canadian product labeling/
Amoxicillin is used, in combination with metronidazole and bismuth subsalicylate, in the treatment of gastritis and peptic ulcer disease caused by Helicobacter pylori. /NOT included in US product labeling; Not included in Canadian product labeling/
Biomedical Effects and Toxicity:
AMOXICILLIN IS MORE RAPIDLY & COMPLETELY ABSORBED FROM GI TRACT THAN IS AMPICILLIN... PEAK PLASMA CONCN ARE REACHED @ 2 HR & AVG ABOUT 4 UG/ML WHEN 250 MG IS ADMIN. ... ABOUT 20%...IS PROTEIN BOUND IN PLASMA... APPROX 60% OF DOSE...IS EXCRETED IN ACTIVE FORM IN URINE.
FOOD HAS NEGLIGIBLE EFFECT ON GI ABSORPTION OF AMOXICILLIN.
ORAL & IM ABSORPTION OF AMOXICILLIN IN HUMANS WAS 93% & 91% OF IV UTILIZATION. PEAK SERUM LEVLES (12 UG/ML APPROX) & TIME TO PEAK LEVELS (1.2 HR) ARE NEARLY IDENTICAL FOR BOTH ROUTES. SLIGHT DELAY & DECR IN PEAK SERUM LEVELS WHEN DOSAGE INCR. [SPYKER ET AL; ANTIMICROB AGENTS CHEMOTHER 11: 132-41 (1977)] PubMed Abstract
CSF LEVELS IN 3 CHILDREN TREATED FOR BACTERIAL MENINGITIS GREATER THAN 1 UG/ML WERE NOT PREDICTABLE & APPEARED TO DEMAND BLOOD LEVELS OF 50 UG/ML. MONITORING OF CSF LEVELS MAY BE NECESSARY TO ENSURE SATISFACTORY OUTCOME.
Amoxicillin is generally stable in the presence of acidic gastric secretions, and 74-92% of a single oral dose of the drug is absorbed from the GI tract. Amoxicillin is more completely absorbed from the GI tract than is ampicillin, and peak serum concn of amoxicillin are generally 2-2.5 times higher than those attained with an equivalent oral dose of ampicillin. As oral dosage of amoxicillin is increased, the fraction of the dose absorbed from the GI tract decreases only slightly and peak serum concn and areas under the serum concn-time curves (AUCs) increase linearly with increasing dosage.
Peak serum concn are usually reached 1-2 hr after oral administration of amoxicillin capsules, tablets, or oral suspension in fasting and non-fasting adults. Following oral administration of a single 250- or 500-mg dose of amoxicillin, peak serum concn range from 3.5-5 or 5.5-11 ug/ml, respectively. In one study in healthy, fasting adults who received a single 500-mg oral dose of amoxicillin, serum concn of the drug averaged 3.3, 6.7, 9.3, 5.8, and 0.6 ug/ml @ 30 min, 1 hr, 2 hr, 3 hr, and 4 hr, respectively, after the dose.
In one study in children 4-45 mo of age receiving amoxicillin oral suspension in a dosage of 15 mg/kg daily, serum amoxicillin concn ranged from 2.4-8.5, 1.9-11.3, 1.7-6.4, 0.17-1.9, and 0.14-3.3 ug/ml @ 30 min, 1 hr, 2 hr, 4 hr, and 6 hr, respectively, after a dose.
Although presence of food in the GI tract reportedly results in lower and delayed peak serum concn of amoxicillin, the total amt of drug absorbed does not appear to be affected.
Pregnant women with GBS colonisation and/or with epidemiologic risk factors received intraparturn antibiotic infusion at the beginning of the labor (l g amoxicillin every 6 hours until the delivery). At delivery, cord blood and gastric fluid were taken infusion. Concentrations were measured in triplicate with a microbilogical method using Bacillus subtillus ATCC 6633 as test strain. In cord blood amoxicillin appeared as early as the first half hour. Concentrations were from 5 to 7 mg/l between 1 hour and 4 hours after the beginning of the infusion and from 3 to 4 mg/l after 4 hours. In gastric fluid, concentrations obtained were over 1 mg/l after 1.5 hour and over 3 mg/l after 2.5 hours, with good efficiency even after the sixth hour. The protocol using a slow intrapartum amoxicillin infusion (1 g) gave concentrations in gastric fluid and cord blood over S. agalactiae MIC. [Delcleve S et al; Pathol Biol (Paris) 42 (5): 516-9 (1994)] PubMed Abstract
Amoxicillin was given as single doses of 375, 700, 1500, 3000, and 6000 mg an oral suspension to four volunteers with an ileostomy and with no active intestinal disease after an overnight fast. The excretion of amoxicillin and its penicilloic acid was followed in samples taken from the ileostomy and in urine produced over 6 hr. Beta-lactanase activity was measured in ileal fluid and none was found. The percentage of the dose recovered from the ileostomy increased successively from 8% at the lowest dose to 77% at the highest dose. A complementary excretion pattern of amoxicillin was found in the urine amounting to 70% recovery at the lowest dose to 23% at the highest dose. The results confirm the dose-dependence of the absorption of amoxicillin which could at least in part be due to specialised absorption of this drug in humans. [Sjovall J et al; Eur J Clin Pharmacol 43 (3): 277-81 (1992)] PubMed Abstract
Chemical Company
Hebei Fude Chemical Technology Co.,Ltd.:
 
Xiamen Yazijin Textile Co.,ltd FC:
Xiamen Yazijin Textile Co.,Ltd. is a professional manufacturer and exporter that is concerned with the design,Website:http://www.luss-encaje.com, development, production and sales of all kinds of lace. We are located in Xiamen City,China with convenient transportation access. Our main products include bridal lace fabric, chemical lace fabric, embroidery lace fabric and stretch/non-stretch lace and the like. All of our products comply with international quality standards and are greatly appreciated in a variety of different markets throughout the world. Been in the line of laces for over 10 years, we have been devoted to supplying fashionable designs and the best products to all our customers. Our well-equipped Facilities and excellent quality control throughout all stages of production  
Huangshan violet Biotechnology Co., Ltd:
Huangshan purple Biotechnology Co., Ltd. started in October 2007, we are situated on the planet famous scenic town of Huangshan in Anhui Province, 50 km from Huangshan Scenic Area, 17 km from Huangshan Airport terminal,and 10km from Huangshan High-speed Rail Station, transportation is extremely convenient. Our organization mainly produces silane -based APIs and pharmaceutical intermediates, special items: Tert-butyldimethylsilylchloride, Triethylsilane, Bromotrimethylsilane, Tert-Butylchlorodiphenylsilane,Triisopropylsilane, n,o-bis(Trimethylsilyl)trifluoroAcetamide, n,o-bis(Trimethylsilyl)Acetamide, Trimethyliodosilane and other chlorine-containing silane intermediates ,DMP etc. Companies depend on strong scientific and technological strength , advanced production techn 
Changzhou Baolong Chemical Industrial Co.,Ltd:
Changzhou Baolong Chemical Industrial Co., LTD is situated at Chemical Industry Park of Xinbei District, Changzhou, Jiangsu Province. It is close by Shanghai-Nanjing Expressway (G42) and Beijing-Shanghai High-speed Railway, Changzhou Station. It likes quite convenient transportation. Being an enterprise exclusively funded by Hong Kong Yuanshin Industry Co., Ltd., having a registered capital of USD ten million, and a complete investment 0f USD 20 million, the organization has changed into a leading manufacturer focused on creating N-methylaniline, which using the designed production capacity at 350,000 tons each year and the present production capacity has accomplished to 150,000 tons each year. mso-ansi-language:EN-USmso-fareast-language:ZH-CNmso-bidi-language:AR-SA">We really are 
JINBEI INDUSTRIAL AND TRADING CO.,LTD:
Our factory Located in Yiwu China,Website:http://www.jbhairaccessories.com, professional in kinds of hair accessories, jewelry and so on. Like hair band, hair clips, headband and fake hair. We have pass the BSCI and AVON Audit,the customer from EUROPE,SOUTH AFRICA, SOUTH AMERICA.  
TianjinJiayouExport and Import CO.ltd:
 
Nanjing Hanrui Cobalt Co.ltd:
Hanrui Cobalt started in 1997, headquartered in Nanjing, Jiangsu, China. Hanrui Cobalt is really a comprehensive enterprise that is an expert in exploitation and refining of cobalt ore,production and sales of Cobalt powder and cobalt chemicals. Presently, Hanrui Cobalt holds Nanjing Hanrui Cobalt, Metal Mines sprl and GT Chemicals by full or part holding. Nanjing Hanrui Cobalt CO., Ltd. produces Cobalt powder and other cobalt chemicals since it's principal items. Included in this, annual production capacity of cobalt powder has arrived at 1200 metallic tons. Our items happen to be broadly identified by home and abroad clients due to high and stable quality. Hanrui Cobalt became one of principal producers and entrepreneurs of cobalt powder around the globe. Ⅰ Ⅰ cobalt powder (CO:99.8%) Ⅰ Ⅰ  
Magicharming Co.,Ltd.:
WW.magicharming.com is Chinese global on-line stock look for beads and Jewellery Making Supplies,offering largest choice of beads and jewellery add-ons in incredible cost, reliable quality and latest styles.The finest benefit of us is we have industrial facilities who manufacture various sandOrlampwork beads/rhinestone beads etc.we have subsidiary plants that have been coinvested or worked with to create various jewellery add-ons for example porcelain beads,covering beads,findings, gem along with other Jewellery components. Because of our strong network of Chinese producers for jewellery supplies and fullrich professional understanding in jewellery line, we are able to offer unbelievable low cost to the clients while keeping the greatest of standards.We has experienced R&D team. The fa 
465724SX54ScsdaAD:
 
XI'AN WESTERN MAGNESTUM CO.LTD:
 
Hubei Yuancheng Saichuang Technology Company:
 
Shan Par Industries:
 
Baisi international co.,limited:
Baisi Hair Factory was established in 2005,Website:http://www.baisihair.com, one of the highly professional experienced 100% virgin human hair design and manufacturers, located in China, providing high quality hair to famous stars and models, with strong supply ability and sufficient stock. We are specialized in supply a wide range of top quality 100% virgin human hair famous around the world. With a wide range, good quality, reasonable prices and stylish designs, our products are extensively used in America, Europe, Asia and Africa. Our products are widely recognized and trusted by users and can meet continuously developing economic and social needs. Our Standard: Best Quality, Best Service, High Reputation, Fast Shipment. Follow Baisi, Shining at everywhere.  
Langfang Yelian Trade Co.,Ltd.:
BeiJing Yelian Chemicals Trade CO.,Ltd. in Langfang City, Hebei Province, the primary product:Metal hydride、Lithium aluminium hydride 、Sodium hydride、Calcium hydroxide 、Lithium hydride、Potassium Borohydride 、 Sodium Borohydride、 Lit_ _hium tri-t-butoxyaluminium Hydride、 Lithium tri-sec-Butylborohydride、 Lithium triethylborohydride、 Zinc Borohydride、 lithium borohydride、 Sulfide Ⅰ Ⅰ Ⅰ 、Methane sulfonyl chloride MSC、 Methanesulfonate、Dimethyl Disulfide,DMDS 、Dimethyl Su_ _lfide、Pharmaceutical and Chemical、 Ellagic Acid、 Siwa 12-PWA、 Zinc Pyrithione、 Copper Pyrithione 、 Pyromellitic ac_ _id、 Pyromellitic dianhydride、 succinic anhydride 、 benzoin、、 Glutaric Acid Ⅰ Ⅰ Ⅰ Ⅰ ETC. Ⅰ Ⅰ Ⅰ Ⅰ The business's items offered through the country, and happen to be released towards the U . s . States, Japan, K 
RIZHAO MEIBONDA BIOLOGICAL TECHNOLOGY CO.,LTD:
 Rizhao Meibonda Biological Technology Co., Ltd.is situated in beautiful ocean town, Rizhao City in Shandong Province. It's a biotechnology enterprise focused on the study, production and purchase of pharmaceutical intermediate, Beauty Items and medical apparatus and instruments.   The establishment of professional technical team, GMP production plant, Complete and strict testing system has guaranteed stable and Advanced manufacturing technique. our prime quality, integrity and global marketing network enable our organization to win high praise home and abroad including in Europe, america, Oceania and Southeast Asia. Because the establishment, our organization demands around the business tenet of &ldquodevelop on science and status first&rdquo. Depending on effective pro 
Guangdong BoHong Medicine Co., Ltd.:
GUANGDONG BO HONG MEDICINE Co., Ltd is really a GSP licensed company, that is a built-in enterprise with R&D, manufacturing, Marketing, distribution, importation &lifier exportation. The items involve in Pharmaceutical Recycleables, Intermediates, Finished Dosage Form and Chemical Material Items, Natural Ingredients, excipients, medical tools, healthy items etc. BO HONG started in 2002, generally dedicated to introduction of recent pharmaceutical drugs from abroad and conveying pharmaceutical drugs around the planet, in addition to developing and manufacturing of recent drugs. Our goal is to setup a bridge of pharmaceutical drugs between China and the planet, and to supply affordable and innovative medications to the clients. The organization has built a comprehensive relationsh 
EMCO chemicals:
 
LiTTLE-PA life science company limited:
 LiTTLE-PA life science company limited(LiTTLE-PA lifescience) was founded  in 2014 by Dr Xin hua Gu from Chinese Academy of Sciences and located  in Wuhan Huagong technology business incubator.We're a science company which mainly involved in the biological and pharmaceutical industry.Since our organization establishment, We have been granted  generous financial support form all levels of provincial, municipal and districtand therefore are continuing to move forward to some mature biological high-tech businesses.Our organization business mainly involves in biochemistry,molecu 
465724SX54ScsdaAD:
 
Weifang Haihon International Co., Ltd:
Weifang haihon International Co., Ltd has focused on top quality hose clamps for over 8 years in China. We started as a small operation,Website:http://www.haihonclamp.com, but now have become one of the leading suppliers in the fastener industry in China. Today, Weifang haihon has been one of the top suppliers of quality hose clamps, such as: German type hose clamps, American type hose clamps. British type hose clamp and Heavy duty clamps.