CAS Search
Related Chemical Product
Chemical Product CAS:122852-69-11H-Pyrido[4,3-b]indol-1-one,2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-,hydrochloride (1:1)

1H-Pyrido[4,3-b]indol-1-one,2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-,hydrochloride (1:1)

  • CAS No:

  • Name:

    1H-Pyrido[4,3-b]indol-1-one,2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-,hydrochloride (1:1)
  • Molecular Formula:

  • Molecular Weight:

Buy Chemical NO: 122852-69-1
  • Urgent Purchase CAS NO.:122852-69-1
  • Please post your buying leads! Our suppliers will contact you later!
  • For suppliers to better understand your request, enter more info here.

* Product Name:
CAS No.:
* Quantity:
 Metric Ton     Kilogram    Gram    Pound
* Valid For:
 5 Days    15    1 Month    3 Month    6 Month    1 Year
* Description:

Max 2000 characters.  Please enter detailed description for the product.
* Email:

1H-Pyrido[4,3-b]indol-1-one,2,3,4,5-tetrahydr ( CASNO:122852-69-1 )

Identification and Related Records
1H-Pyrido[4,3-b]indol-1-one,2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-,hydrochloride (1:1)
CAS Registry number:
Iupac name:
3-b]indol-1-one hydrochloride
Alosetron HCl
1H-Pyrido[4,3-b]indol-1-one,2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-,monohydrochloride (9CI)
GR 68755C
Molecular Formula:
Molecular Weight:
Canonical SMILES:
Chemical and Physical Properties
Off-white powder
Melting Point:
Boiling Point:
648.1 °C at 760 mmHg
1.1E-16mmHg at 25°C
Flash Point:
345.8 °C
Computed Properties:
Molecular Weight:330.81196 [g/mol]
Molecular Formula:C17H19ClN4O
H-Bond Donor:2
H-Bond Acceptor:1
Rotatable Bond Count:2
Tautomer Count:2
Exact Mass:330.124739
MonoIsotopic Mass:330.124739
Topological Polar Surface Area:53.9
Heavy Atom Count:23
Formal Charge:0
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:2
Safety and Handling
The main ingredient in the drug Lotronex ... (tablets)
Exposure Standards and Regulations:
The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl alosetron hydrochloride, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.
Disposal Methods:
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Use and Manufacturing
Use and Manufacturing:
Methods of Manufacturing

Preparation: I.H. Coates et al., EP 306323; eidem, US 5360800 (1989, 1994 both to Glaxo)
Serotonin 5HT3-receptor antagonist. Used in treatment of irritable bowel syndrome
Biomedical Effects and Toxicity
Pharmacological Action:
- Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
- Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
Therapeutic Uses:
Alosetron, a selective 5-HT3-receptor antagonist, is indicated for the treatment of irritable bowel syndrome in female patients whose predominant symptom is diarrhea. /Salt not specified/
... Animal models have shown it to be active in anxiety, psychosis, cognitive impairment, emesis & drug withdrawal, though its application in humans has been almost entirely restricted to irritable bowel syndrome (IBS). ... Alosetron appears promising in the treatment of abdominal pain & discomfort & normalising of bowel function in patients with non-constipated IBS. It also improves quality of life, has a high degree of tolerability & has an excellent safety profile to date. /Salt not specified/ [Camilleri M; Expert Opin Investig Drugs 9(1): 147-159 (2000)]
Biomedical Effects and Toxicity:
Absorption is rapid and ranges from 30 to > 90% after oral administration. /Salt not specified/
Alosetron ... is absorbed rapidly after oral admin & is widely distributed throughout tissues after oral or iv. dosing in animals. Its metab is rapid & extensive with N-demethylation, hydroxylation & oxidation. The drug, or its two principal metabolites, is equally excreted through the biliary tract & kidneys. Alosetron has proved safe in a range of toxicity studies; at high repeated dosing, clinical signs were transient & repeated admin produced no significant adverse effects on fertility, reproductive performance or fetal development. In pharmacokinetic studies, bioavailability of alosetron in healthy volunteers is approx 60% & the plasma half-life is about 1.5 hr. There are some gender differences in the pharmacokinetic profile, with 30-50% higher alosetron concns in females. No consistent differences in alosetron serum concns between the young & elderly were observed. The pharmacokinetics of single, oral doses of alosetron are linear up to 8 mg. ... /Salt not specified/ [Camilleri M; Expert Opin Investig Drugs 9(1): 147-159 (2000)] PubMed Abstract
Chemical Company
LASA Electronics Technology Co., Ltd:
LASAET is a professional supplier of handheld terminal,Website:,PDA,Android printer terminal with factory in Shenzhen,China,also provide the extend products,such as mobile printer,1D bar code scanner.QR barcode is your best assistant for retail management,logistics management,inventory management,parking management,POS solution,will increase your working efficiency and reduce your labor and time cost! Why Select us? Professional Quick response Technical Support Best after-sales service For more detail information,please visit :  
Dotogo Tecchnologies Co.,Ltd:
Dotogo Technologies found in China,Website:, as a leading manufacturer that provide global high-speed television via satellite to mobile users on land and at sea.Dotogo product including fully automatic Caravan antenna and Flat panel antenna for Motor Home and Caravan Travellers; as well as Marine Satellite TV receiver for all sorts of boats/yachts/ships. All products brings the very best in quality, design and technology to Motorhome, Caravan and Marine Market all over the world. 
Gaoyou Guangming Chemical Factory:
Gaoyou Guangming Chemical Factory is situated in Baqiao Town, Gaoyou City, Jiangsu Province. It's close to the Beijing-Shanghai expressway in the western world, therefore the transportation is extremely convenient. Our new factory occupies 18,000 square meter space on the floor and presently has greater than 120 employees. It is the owner of greater than 20 million RMB fixed assets and has transpired the ISO9002 Authentication. Our factory continues to be approved to achieve the Self-support Export-Import Procedures Right through the National Move Ministry.( The custom code is 3210950817) The enterprise is among the national research and production specialized models around the fluoride, chloride series along with other medications, Farming Chemicals and dye intermediates. it present 
Chongqing new and high technology industry development zone zhaoguang locomotive accessory factory:
mephedroneplant plc:
Shanghai THC International Co.,Ltd.:
 Tuhuang a number one chemical manufacturer and supplier came from to 1983. We offer rubber industries and other industries with quality material, professional solutions inside a timely and reliable manner. 
Wuhan Demeikai Biotechnology Co. Ltd.:
Shaoxing Jinchuang knitting Co.,Ltd:
Anufacturing Knitted Fabrics Since 2002 Founded 2002, Jinchuang Knitting is an expert in conveying and manufacturing cotton and polyester knitted materials. For more than one decade, Purchasers in Europe and South Usa happen to be depending on the knowledge of developing and conveying sportswear materials. Our mainly item is polar fleece and Knitted Materials.We comprehend the quality concerns in our purchasers. That's the reason each piece in our knitting materials exceeds stringent ITS Class 4 testing standard in colorfastness to washing and to light.Our multifunctional materials are waterproof, Antibacterial and Fluoresent, which makes them well suited for a multitude of programs from aquatic sports to safe clothing. Additionally they feature enhanced breathing abilities. Your Custo 
Shandong Panze Chemical Science Co., Ltd:
Dongyang Xingtai Glitter Powder Co., Ltd.:
Our Factory Established in 1990,Website:, Xingtai Glitter Company is a professional manufacturer of making series of glitter, with machines imported from Germany and USA, we supply our customers gold, silver, rainbow, laser and holoshade glitter power in tetragon an hexagon. We are very confident that we can supply various kind of sizes and colors to meet different customer's requests. Our Product Glitter powder, glitter powder shaker, glitter flake, sequins, glitter film. 12 Product Application Our product applies in Children DIY and Craft Education, Christmas Gift, Silkscreen printing, Cosmetics, Decorative material, Candle craft, Varnish decoration, etc. With the adornment advantage, the glitter make the product have the Art Characteristic and significan 
Wuhan Healthgen Biotechnology Corp.:
Our History Established in 2014,Website:, Fujian Dehua Tianci Art Ceramics Co.,Ltd. is a professional manufacturer and exporter that is concerned with the design, development and production of ceramic items. We are located in Dehua China, one of the most famous ceramic production base in China. Our Factory Covering an area of 10000 square meters, we now have over 120 employees, an annual sales figure that exceeds USD2,000,000 and are currently exporting 95% of our production worldwide.Our Product Main Products includes the following: 1, Ceramic cookie jars 2, Ceramic kitchen ware 3, Ceramic mugs 4, Ceramic bathroom set. 5, Ceramic flower pot 6, Ceramic money bank 7, Ceramic oil burner 8, Ceramic home decoration. Product Application Our ceramic products are widely  
Puyang Lixin Fine Chemical Co., Ltd: